Small Animal Clinical Nutrition

The most comprehensive and practical small animal nutrition resource available.

Chapter 69: Effects of Food on Pharmacokinetics References


Abernethy DR, Greenblatt DJ, Divoll M, et al. The influence of obesity on the pharmacokinetics of oral alprazolam and triazolam. Clinical Pharmacokinetics 1984; 9: 177-183.

Allard S, Kinzig M, Boivin G, et al. Intravenous ciprofloxacin disposition in obesity. Clinical Pharmacology and Therapeutics 1993; 54: 368-373.

Anderson KE, Kappas A. Dietary regulation of cytochrome P-450. Annual Review of Nutrition 1991; 11: 141-167.

Anderson RA, Polansky MM, Bryden NA, et al. Supplemental chromium effects on glucose, insulin, glucagon, and urinary chromium losses in subjects consuming controlled low-chromium diets. American Journal of Clinical Nutrition 1991; 54: 909-916.

Bartges JW, Osborne CA, Felice LJ, et al. Influence of two diets on pharmacokinetic parameters of allopurinol and oxypurinol in healthy beagles. American Journal of Veterinary Research 1997; 58: 511-515.

Bedford PGC, Clarke EGC. Suspected benzoic acid poisoning in the cat. Veterinary Record 1971; 88: 599-601.

Behrend EN, Grauer GF, Greco DS, et al. Effects of dietary protein conditioning on gentamicin pharmacokinetics in dogs. Journal of Veterinary Pharmacology and Therapeutics 1994; 17: 259-264.

Benet LZ, Hoener BA. Changes in plasma protein binding have little clinical relevance. Clinical Pharmacology and Therapeutics 2002; 71: 115-121.

Bentley JB, Vaughan RW, Gondolfi AJ, et al. Halothane biotransformation in obese and nonobese patients. Anesthesiology 1982; 57: 94-97.

Berlinger WG, Park GD, Spector R. The effect of dietary protein on the clearance of allopurinol and oxypurinol. New England Journal of Medicine 1985; 313: 771-776.

Boden G, Chen X, Ruiz J, et al. Effects of vanadyl sulfate on carbohydrate and lipid metabolism in patients with non-insulin dependent diabetes mellitus. Metabolism 1996; 45: 1130-1135.

Brinker KR, Bulger RE, Dobyan DC, et al. Effect of potassium depletion on gentamicin nephrotoxicity. Journal of Laboratory and Clinical Medicine 1981; 98: 292-301.

Brown SA, Riviere JE. Comparative pharmacokinetics of aminoglycoside antibiotics. Journal of Veterinary Pharmacology and Therapeutics 1991; 14: 1-35.

Bueno L, Praddaude F, Fioramonti J, et al. Effect of dietary fiber on gastrointestinal motility and jejunal transit time in dogs. Gastroenterology 1981; 80: 701-707.

Burrows CF, Bright RM, Spencer CP. Influence of dietary composition on gastric emptying and motility in dogs: Potential involvement in acute gastric dilatation. American Journal of Veterinary Research 1985; 46: 2609-2612.

Campbell BG, Rosin E. Effect of food on absorption of cefadroxil and cephalexin in dogs. Journal of Veterinary Pharmacology and Therapy 1998; 21(5): 418-420.

Campbell NR, Hasinoff BB, Stalts H, et al. Ferrous sulfate reduces thyroxine efficacy in patients with hypothyroidism. Annals of Internal Medicine 1992; 117: 1010-1013.

Caraco Y, Zylber-Katz E, Berry EM, et al. Significant weight reduction in obese subjects enhances carbamazepine elimination. Clinical Pharmacology and Therapeutics 1992; 51: 501-506.

Catz CS, Juchau MR, Yaffe SJ. Effects of iron, riboflavin and iodide deficiencies on hepatic drug metabolizing enzyme systems. Journal of Pharmacology and Experimental Therapeutics 1970; 174: 197-205.

Chow HH, Lalka D. Pharmacokinetics of d-propranolol following oral, intra-arterial and intraportal administration: Contrasting effects of oral glucose pretreatment. Biopharmaceutics and Drug Disposition 1993; 14: 217-231.

Christopher MM, Perman V, Eaton JW. Contribution of propylene glycol-induced Heinz body formation to anemia in cats. Journal of the American Veterinary Medical Association 1989; 194: 1045-1056.

Corcoran GB, Salazar DE, Chan HH. Obesity as a risk factor in drug induced organ injury. III. Increased liver and kidney injury by furosemide in the obese overfed rat. Toxicology and Applied Pharmacology 1989; 98: 12-24.

Corcoran GB, Salazar DE. Obesity as a risk factor in drug-induced organ injury. IV. Increased gentamicin nephrotoxicity in the obese overfed rat. Journal of Pharmacology and Experimental Therapeutics 1989; 248: 17-22.

Corcoran GB, Wong BK. Obesity as a risk factor in drug-induced organ injury: Increased liver and kidney damage by acetaminophen in the obese overfed rat. Journal of Pharmacology and Experimental Therapeutics 1987; 241: 921-927.

Danforth E, Burger AG. The impact of nutrition on thyroid hormone physiology and action. Annual Review of Nutrition 1989; 9: 201-227.

DeLong MJ, Prohaska HJ, Talalay P. Tissue-specific induction patterns of cancer-protective enzymes in mice by tert-butyl-4-hydroxyanisole and related substituted phenols. Cancer Research 1985; 45: 546-551.

Drew B, Barber WP, Williams DG. The effect of excess dietary iodine on pregnant mares and foals. Veterinary Record 1975; 97: 93-95.

Driscoll J, Hintz HF, Schryver MF. Goiter in foals caused by excessive iodine. Journal of the American Veterinary Medical Association 1978; 173: 858-859.

Ducharme MP, Slaughter RL, Edwards DJ. Vancomycin pharmacokinetics in a patient population: Effect of age, gender, and body weight. Therapeutic Drug Monitoring 1994; 16: 513-518.

Dunn TE, Ludwig EA, Slaughter RL, et al. Pharmacokinetics and pharmacodynamics of methylprednisolone in obesity. Clinical Pharmacology and Therapeutics 1991; 49: 536-549.

Elfant AB, Levine SM, Peikin SR, et al. Ferrous sulfate reduces thyroxine efficacy in patients with hypothyroidism. Annals of Internal Medicine 1992; 117: 1010-1013.

Fagan TC, Walle T, Oexmann MJ, et al. Increased clearance of propranolol and theophylline by high-protein compared with high-carbohydrate diet. Clinical Pharmacology and Therapeutics 1987; 41: 402-406.

Fettman MJ, Butler RN, McMichael AJ, et al. Metabolic phenotypes and colorectal neoplasia. Journal of Gastroenterology and Hepatology 1991; 6: 81-90.

Fettman MJ, Coble JM, Hamar DW, et al. Effect of dietary phosphoric acid supplementation on acid-base balance and mineral and bone metabolism in adult cats. American Journal of Veterinary Research 1992; 53: 2125-2135.

Fettman MJ. Comparative aspects of glutathione metabolism affecting individual susceptibility to oxidant injury. Compendium on Continuing Education for the Practicing Veterinarian 1991; 13: 1079-1091.

Fettman MJ. Potential benefits of psyllium mucilloid supplementation of oral replacement formulas for neonatal calf scours. Compendium on Continuing Education for the Practicing Veterinarian 1992; 14: 247-255.

Fleisher D, Sheth N, Kou JH. Phenytoin interaction with enteral feedings administered through nasogastric tubes. Journal of Parenteral and Enteral Nutrition 1990; 14: 513-516.

Fleming RA, Eldridge RM, Johnson CE, et al. Disposition of high-dose methotrexate in an obese cancer patient. Cancer 1991; 68: 1247-1250.

Grauer GF, Greco DS, Behrend EN, et al. Effects of dietary protein conditioning on gentamicin-induced nephrotoxicosis in healthy male dogs. American Journal of Veterinary Research 1994; 55: 90-97.

Guengerich FP. Effects of nutritive factors on metabolic processes involving bioactivation and detoxication of chemicals. Annual Review of Nutrition 1984; 4: 207-231.

Guengerich FP. Influence of nutrients and other dietary materials on cytochrome P-450 enzymes. American Journal of Clinical Nutrition 1995; 61 (Suppl.): 651S-658S.

Guyton KZ, Bhan P, Kuppusamy P, et al. Free radical-derived quinone methide mediates skin tumor promotion by butylated hydroxytoluene hydroperoxide: Expanded role for electrophiles in multistage carcinogenesis. Proceedings of the National Academy of Sciences 1991; 88: 946-950.

Hall JC, Heel K, McCauley R. Glutamine. British Journal of Surgery 1996; 83: 305-312.

Havrankova J, Lahaie R. Levothyroxine binding by sucralfate. Annals of Internal Medicine 1992; 117: 445-446.

Heddle R, Collins PJ, Dent J, et al. Motor mechanisms associated with slowing of the gastric emptying of a solid meal by an intraduodenal lipid infusion. Journal of Gastroenterology and Hepatology 1989; 4: 437-447.

Heddle R, Fone D, Dent J, et al. Stimulation of pyloric motility by intraduodenal dextrose in normal subjects. Gut 1988; 29: 1349-1357.

Horowitz M, Maddox A, Bochner M, et al. Relationships between gastric emptying of solid and caloric liquid meals and alcohol absorption. American Journal of Physiology 1989; 257: G291-G298.

Kaplan AJ. Onion powder in baby food may induce anemia in cats. Journal of the American Veterinary Medical Association 1995; 207: 1405.

Kirk SJ, Barbul A. Role of arginine in trauma, sepsis, and immunity. Journal of Parenteral and Enteral Nutrition 1990; 14: 226S-229S.

Knodell RG, Steele NM, Cerra FB, et al. Effects of parenteral and enteral hyperalimentation on hepatic drug metabolism in the rat. Journal of Pharmacology and Experimental Therapeutics 1984; 229: 589-597.

KuKanich B, Papich M. Fluoroquinolone stability in vehicles for oral administration. Journal of Veterinary Internal Medicine 2003; 17: 449.

Kung K, Hauser BR, Wanner M. Effect of the interval between feeding and drug administration on oral ampicillin absorption in dogs. Journal of Small Animal Practice 1995; 36: 65-68.

Liel Y, Sperber AD, Shany S. Nonspecific intestinal adsorption of levothyroxine by aluminum hydroxide. American Journal of Medicine 1994; 97: 363-365.

Maguire PJ, Fettman MJ, Smith MO, et al. Effects of diet on pharmacokinetics of phenobarbital in healthy dogs. Journal of the American Veterinary Medical Association 2000; 217: 847-852.

McCarthy DM. Sucralfate. New England Journal of Medicine 1991; 325: 1017-1025.

Meydani SN. Effect of (n-3) polyunsaturated fatty acids on cytokine production and their biological function. Nutrition 1996; 12: S8-S14.

Mounie J, Faye B, Magdalou J, et al. Modulation of UDP-glucuronyl transferase activity in rats by dietary lipids. Journal of Nutrition 1986; 116: 2034-2043.

Nugon-Boudon L, Roland N, Flinois JP, et al. Hepatic cytochrome P-450 and UDP-glucuronosyl transferase are affected by five sources of dietary fiber in germ-free rats. Journal of Nutrition 1996; 126: 403-409.

Pantuck EJ, Pantuck CB, Kappas A, et al. Effects of protein and carbohydrate content of diet on drug conjugation. Clinical Pharmacology and Therapeutics 1991; 50: 254-258.

Park GD, Spector R, Kitt TM. Effect of dietary protein on renal tubular clearance of drugs in humans. Clinical Pharmacokinetics 1989; 17: 441-451.

Parke DV, Ioannides C. The role of nutrition in toxicology. Annual Review of Nutrition 1981; 1: 207-234.

Parker WA, MacCara ME. Compatibility of diazepam with intravenous fluid containers and administration sets. American Journal of Hospital Pharmacy 1980; 37(4): 496-500.

Pepine CJ. The therapeutic potential of carnitine in cardiovascular disorders. Clinical Therapeutics 1991; 13: 2-21.

Quarum ML, Houghton DC, Gilbert DN, et al. Increasing dietary calcium moderates experimental gentamicin nephrotoxicity. Journal of Laboratory and Clinical Medicine 1984; 103: 104-114.

Raftogianis RB, Franklin MR, Glainsky RE. The depression of hepatic drug conjugation reactions in rats after lipid-free total parenteral nutrition administered via the portal vein. Journal of Parenteral and Enteral Nutrition 1995; 19: 303-309.

Reidenberg MM. Obesity and fasting–Effects on drug metabolism and drug action in man. Clinical Pharmacology and Therapeutics 1977; 22: 729-733.

Reppas C, Meyer JH, Sirois PJ, et al. Effect of hydroxypropylmethylcellulose on gastrointestinal transit and luminal viscosity in dogs. Gastroenterology 1991; 100: 1217-1223.

Roe DA. In: Diet and Drug Interactions. New York, NY: Van Nostrand Reinhold, 1989.

Rogers AE. Methyl donors in the diet and responses to chemical carcinogens. American Journal of Clinical Nutrition 1995; 61 (Suppl.): 659S-665S.

Schumacher J, Wilson RC, Spano JS, et al. Effect of diet on gentamicin-induced nephrotoxicosis in horses. American Journal of Veterinary Research 1991; 52: 1274-1278.

Schwartz AE, Matteo RS, Ornstein E, et al. Pharmacokinetics of sufentanil in obese patients. Anesthesia and Analgesia 1991; 73: 790-793.

Sellke FW, Tomanek RJ, Harrison DG. L-cysteine selectively potentiates nitroglycerin-induced dilation of small coronary microvessels. Journal of Pharmacology and Experimental Therapeutics 1991; 258: 365-369.

Semple HA, Koo W, Tam YK, et al. Interactions between hydralazine and oral nutrients in humans. Therapeutic Drug Monitoring 1991; 13: 304-308.

Shum L, Jusko WJ. Theophylline disposition in obese rats. Journal of Pharmacology and Experimental Therapeutics 1984; 228: 380-386.

Spence RK, Camishion RC. Bioavailability of medication delivered via nasogastric tube is decreased in the immediate postoperative period. American Journal of Surgery 1995; 169: 430-432.

Toothaker RD, Welling PG. The effect of food on drug bioavailability. Annual Review of Pharmacology and Toxicology 1980; 20: 173-199.

Umegaki K, Ikegami S, Ichikawa T. Fish oil enhances pentachlorobenzene metabolism and reduces its accumulation in rats. Journal of Nutrition 1995; 125: 147-153.

Waters B, Kudsk KA, Jarvi EJ, et al. Effect of route of nutrition on recovery of hepatic organic anion clearance after fasting. Surgery 1994; 115: 370-374.

Watson ADJ, Egerton JR. Effect of feeding on plasma antibiotic concentrations in greyhounds given ampicillin and amoxicillin by mouth. Journal of Small Animal Practice 1977; 18: 779-786.

Watson ADJ, Emslie DR, Martin ICA, et al. Effect of ingesta on systemic availability of penicillins administered orally in dogs. Journal of Veterinary Pharmacology and Therapeutics 1986; 9: 140-149.

Webb CB, Twedt DC, Fettman MJ, et al. S-adenosylmethionine (SAMe) in a feline acetaminophen model of oxidative injury. Journal of Feline Medicine and Surgery 2003; 5: 69-75.

Wilkie DA, Kirby R. Methemoglobinemia associated with dermal application of benzocaine cream in a cat. Journal of the American Veterinary Medical Association 1988; 192: 85-86.

Williams L, Davis JA, Lowenthal DT. The influence of food on the absorption and metabolism of drugs. Medical Clinics of North America 1993; 77: 815-829.

Wong NLM, Magil AB, Dirks JH. Effect of magnesium diet in gentamicin-induced acute renal failure in rats. Nephron 1989; 51: 84-88.

Yang CS, Brady JF, Hong JY. Dietary effects on cytochromes P-450, xenobiotic metabolism and toxicity. Federation of American Societies for Experimental Biology Journal 1992; 6: 737-744.

Yoo JSK, Smith TJ, Ning SM, et al. Modulation of the levels of cytochromes P-450 in rat liver and lung by dietary lipid. Biochemical Pharmacology 1992; 43: 2535-2542.

Yuk J, Nightingale CH, Sweeney K, et al. Pharmacokinetics of nafcillin in obesity. Journal of Infectious Diseases 1988; 157: 1088-1089.



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